Beraprost is an oral prostacyclin (PGI2) analogue specially used in veterinary medicine to improve renal blood flow and microcirculation in cats suffering from chronic kidney disease (CKD). It helps reduce intraglomerular pressure, supports better kidney perfusion, and may slow the progression of renal damage, especially in IRIS Stage 2-4 cats.
Key Benefits
- Improves renal blood flow and glomerular filtration
- Reduces proteinuria
- May help stabilise or slightly lower creatinine and BUN in certain cases
- Anti-platelet and vasodilatory effects help prevent micro-thrombi in damaged kidneys
- Published veterinary studies (mainly Japan and Europe) show improved survival time and quality of life when used as part of CKD management
Administration
Given once or twice daily with or without food. Starting with a lower dose and gradual increase minimises side effects. Always combine with standard CKD management (low-phosphorus diet, phosphate binders, fluids, blood-pressure control).
Dosage
0.03-0.12 mg/kg once daily (most common range 0.05-0.08 mg/kg PO q24h). Typical dose for a 4 kg cat: 0.2-0.4 mg total per day (often compounded into 0.1 mg or 0.2 mg capsules/tablets). Dosage must be tailored by your veterinarian based on blood work, blood pressure, and clinical response.
Side Effects
- Mild gastrointestinal upset (soft stool, vomiting, reduced appetite) - usually transient
- Facial flushing or warmth (rare)
- Hypotension if overdosed (lethargy, weakness) Most side effects are dose-dependent and resolve with temporary dose reduction.