EIDD-1931 (NHC) - Antiviral Support for Feline Herpesvirus Calicivirus Stomatitis

EIDD-1931 (NHC) - Antiviral Support for Feline Herpesvirus Calicivirus Stomatitis

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EIDD-1931 (N-hydroxycytidine, NHC) is an investigational nucleoside analog with broad antiviral and immunomodulatory potential. In veterinary research and clinical practice, EIDD-1931 has attracted interest as a supportive treatment option for cats with chronic feline stomatitis, particularly in cases suspected to be associated with viral persistence (e.g., calicivirus, herpesvirus) and immune-mediated inflammation.

By interfering with viral RNA replication and potentially reducing viral-driven immune activation, EIDD-1931 may help alleviate oral inflammation, pain, and ulceration, improving feeding behaviour and quality of life in affected cats.

EIDD-1931 is incorporated into viral RNA during replication, causing lethal mutagenesis that prevents viable virus production. In cats with chronic stomatitis—where viral persistence may perpetuate immune dysregulation—this mechanism may help reduce viral load and downstream inflammatory responses.
⭐ Key Benefits

🦷 Supports management of chronic feline stomatitis

🧬 Broad-spectrum antiviral mechanism

🔬 Targets viral replication through error catastrophe

🔥 May reduce virus-driven oral inflammation

🍽️ Potential improvement in appetite and oral comfort

🐱 Option for cats unresponsive to steroids, antibiotics, or dental extraction alone
💊 Usage & Dosage

Route: Oral (capsule or compounded liquid)
Indication: Investigational support for feline stomatitis

Commonly reported investigational dosing range (off-label):

4–10 mg/kg orally, once or twice daily

Treatment duration: 7–14 days, adjustable based on clinical response

⚠️ Dosage must be determined and supervised by a licensed veterinarian.
Individual dosing may vary depending on:

Severity of stomatitis

Body weight

Concurrent infections

Liver and kidney function

Other medications being administered
⚠️ Side Effects

Based on limited veterinary experience and extrapolated data, potential side effects may include:

Mild gastrointestinal upset (vomiting, soft stool)

Transient lethargy

Decreased appetite (uncommon)

Rare elevation of liver enzymes with prolonged use

📌 Discontinue and consult a veterinarian if adverse reactions occur.
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