Sirolimus (Rapamune® / Rapamycin) – Advanced Support for Feline Hypertrophic Cardiomyopathy (HCM)
Sirolimus (Rapamune® / Rapamycin) – Advanced Support for Feline Hypertrophic Cardiomyopathy (HCM)
Sirolimus (Rapamune® / Rapamycin) – Advanced Support for Feline Hypertrophic Cardiomyopathy (HCM)
Sirolimus (Rapamune® / Rapamycin) – Advanced Support for Feline Hypertrophic Cardiomyopathy (HCM)

Sirolimus (Rapamune® / Rapamycin) – Advanced Support for Feline Hypertrophic Cardiomyopathy (HCM)

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Sirolimus (Rapamune® / Rapamycin) is an conditional FDA-approved mTOR inhibitor widely studied in veterinary medicine. In recent veterinary cardiology research, Sirolimus has shown promising potential in the management of hypertrophic cardiomyopathy (HCM) in cats, particularly for slowing disease progression and improving cardiac function under veterinary supervision.

Sirolimus works by selectively inhibiting the mammalian target of Rapamycin (mTOR) pathway, a key regulator of:

  • Cellular growth and proliferation

  • Pathological myocardial hypertrophy

  • Cardiac remodeling and fibrosis

In feline HCM, dysregulation of the mTOR pathway is believed to contribute to abnormal thickening of the ventricular walls. Sirolimus may help slow or modulate this pathological process, rather than simply managing symptoms.
⭐ Key Benefits

Supports management of feline hypertrophic cardiomyopathy (HCM)

May help reduce myocardial hypertrophy progression

Targets underlying cellular signalling, not just symptoms

Used in emerging feline cardiology protocols

Can be combined with standard HCM therapies when clinically appropriate
💊 Usage & Dosage

Approximately 0.1-0.3 mg per cat,

Administered once weekly or every 48-72 hours,
depending on body weight, disease stage, and clinical response.

Do not adjust dosage without veterinary instruction.
⚠️ Side Effects

As with all immunomodulatory agents, side effects are possible and may include:

Gastrointestinal upset (vomiting, diarrhea, reduced appetite)

Lethargy or behavioral changes

Delayed wound healing

Increased susceptibility to infections (rare at low veterinary doses)

Altered lipid or liver enzyme levels (monitoring advised)

If adverse reactions occur, discontinue use and consult a veterinarian immediately.
❗ Importance

The tablet is not allowed splitting or breaking coat to administer.

It is highly recommended to be used under direct supervision of a veterinary cardiologist. Regular blood work (CBC, chemistry, trough levels) as well as ultrasound are essential for safe long-term use.
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